Reviews of Physiology, Biochemistry and Pharmacology - 9783540002284
  • Reviews of Physiology, Biochemistry and Pharmacology - 9783540002284

Reviews of Physiology, Biochemistry and Pharmacology - 9783540002284

New: A new, unread, unused book in perfect condition with no missing or damaged pages. See the ... Read moreabout the conditionNew: A new, unread, unused book in perfect condition with no missing or damaged pages. See the seller's listing for full details. See all condition definitionsopens in a new window or tab
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Description
Protein transport events occurring at the endoplasmic reticulum (ER) of eukaryotic cells and the cytoplasmic membrane of prokaryotic organisms share many similarities. Resident proteins of both membranes span the lipid bilayer once or several times by a-helical stretches and their integration is usually mediated by uncleaved signal-anchor sequences. Proteins that are translocated across either membrane, collectively also termed secretory proteins, harbour cleavable N-terminal signal sequences. Prokaryotic and eukaryotic signal sequences have the same modular structure and are functionally exchangeable. Integration of membrane proteins and translocation of secretory proteins basically occur at the same sites (pores) within each membrane. In both types of membranes, these pores are c- posed of homologous components forming the Sec translocons. Parts of the Sec trans- cons are found populated by ribosomes, the membrane-bound ribosomes. Bacterial m- brane and eukaryotic secretory proteins are targeted to the Sec translocons by the same molecular mechanism involving signal recognition particle (SRP) and its receptor (SRP - ceptor, SR). Structure and assembly of the SRP The functional core of SRP The functional core of this ribonucleoprotein complex consists of the signal sequence binding subunit (SRP54 in eukaryotes and Ffh in prokaryotes) and the SRP RNA molecule (see Fig. 1). This core is conserved in all organisms, with the intriguing exception of chloroplasts, where the SRP lacks the RNA subunit.
Product Details
10 Items

Data sheet

Type
Textbook
Author
Not Available
Format
Hardcover
Language
English
Item Height
235mm
Item Width
155mm
Number of Pages
218 Pages
Item Weight
512g
Publisher
M. Galanski, M. Fluck, B.K. Keppler, M. Muller, H. Hoppeler, H.-G. Koch, G. Burckhardt, M. Moser, M.A. Jakupec, B.C. Burckhardt, Springer-Verlag Berlin AND Heidelberg Gmbh & Co. KG
Publication Year
2003

Specific References

ISBN
9783540002284
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